CitizenVectron Posted October 21, 2019 Share Posted October 21, 2019 https://www.cnet.com/news/breakthrough-gene-editing-tool-can-find-and-replace-dna-better-than-crispr/ Quote The ability to edit the genes of human beings by changing the code of life -- DNA -- has dramatically improved over the last decade. Current tools, like CRISPR-Cas9 and base editors, are extremely powerful but have traditionally suffered from a lack of precision, high error rate and limited scope, hampering their ability to treat human genetic disease. A breakthrough gene-editing tool, developed by a team of researchers at Harvard University and unveiled Monday, has the ability to make extremely precise DNA edits, ushering in a new era of genetic manipulation. "In many respects this first report is the beginning rather than the end of a longstanding aspiration ... to be able to make any DNA change in any position of a living cell or organism including, potentially, human patients with genetic diseases," says David Liu, a chemist at Harvard's Broad Institute and co-author of the new study. Quote To demonstrate this, the team corrected the genetic mutations for two human genetic diseases, sickle cell and Tay-Sachs disease, in human cells. They showed the necessary edits could be made to the DNA to reverse the genetic mutations causing those diseases. And it doesn't end with sickle cell and Tay-Sachs. Because prime editing provides one of the most precise ways to manipulate the code of life, the authors hypothesize it could enable treatment for approximately 89% of the 75,112 human genetic mutations that cause disease. Big news, if it holds up. Quote Link to comment Share on other sites More sharing options...
Mr.Vic20 Posted October 21, 2019 Share Posted October 21, 2019 Does it cure outbreaks of misplaced nationalism and xenophobia? We could really use a cure for those right about now! 1 1 Quote Link to comment Share on other sites More sharing options...
TheLeon Posted October 21, 2019 Share Posted October 21, 2019 But Facebook told me that genetically modified foods are bad, so I'm just going to assume that this also bad. Quote Link to comment Share on other sites More sharing options...
CitizenVectron Posted October 21, 2019 Author Share Posted October 21, 2019 7 minutes ago, TheLeon said: But Facebook told me that genetically modified foods are bad, so I'm just going to assume that this also bad. It is, but only if you eat the people who get the Corn gene. Quote Link to comment Share on other sites More sharing options...
Chadatog Posted October 21, 2019 Share Posted October 21, 2019 Can't wait for our new world of Cronenbergs Quote Link to comment Share on other sites More sharing options...
TomCat Posted October 21, 2019 Share Posted October 21, 2019 it wong happen cause there is no money in curing things the money is in the treatment. thats why Nothing has been cured in decades even doe we've had dna for many many decades Quote Link to comment Share on other sites More sharing options...
mclumber1 Posted October 21, 2019 Share Posted October 21, 2019 6 minutes ago, TomCat said: it wong happen cause there is no money in curing things the money is in the treatment. thats why Nothing has been cured in decades even doe we've had dna for many many decades K Mr. President Quote Link to comment Share on other sites More sharing options...
Uaarkson Posted October 21, 2019 Share Posted October 21, 2019 7 minutes ago, TomCat said: it wong happen cause there is no money in curing things the money is in the treatment. thats why Nothing has been cured in decades even doe we've had dna for many many decades This is an astonishing post. Quote Link to comment Share on other sites More sharing options...
Anathema- Posted October 21, 2019 Share Posted October 21, 2019 9 minutes ago, TomCat said: it wong happen cause there is no money in curing things the money is in the treatment. thats why Nothing has been cured in decades even doe we've had dna for many many decades I too was a fan of Chris Rock in 1999. Quote Link to comment Share on other sites More sharing options...
legend Posted October 22, 2019 Share Posted October 22, 2019 Pretty promising. Delivery still seems to remain a big hurdle though and it doesn't seem like this helps. Quote Link to comment Share on other sites More sharing options...
CastlevaniaNut18 Posted October 22, 2019 Share Posted October 22, 2019 1 hour ago, TomCat said: it wong happen cause there is no money in curing things the money is in the treatment. thats why Nothing has been cured in decades even doe we've had dna for many many decades I don't even know where to begin with this stupidity... Quote Link to comment Share on other sites More sharing options...
Jason Posted October 22, 2019 Share Posted October 22, 2019 1 hour ago, TomCat said: it wong happen cause there is no money in curing things the money is in the treatment. thats why Nothing has been cured in decades even doe we've had dna for many many decades Quote Link to comment Share on other sites More sharing options...
Massdriver Posted October 22, 2019 Share Posted October 22, 2019 My eye doctor started talking about how they have probably had a cure for cancer, but money has kept it from the public. I was disappointed. A lot of really intelligent people still believe these conspiracies unfortunately. If such conspiracies were true, that would mean that a lot of lower paid research scientists have all decided not to blow a whistle on the ethics of holding it all back which is implausible. Quote Link to comment Share on other sites More sharing options...
Kal-El814 Posted October 22, 2019 Share Posted October 22, 2019 1 hour ago, TomCat said: it wong happen cause there is no money in curing things the money is in the treatment. thats why Nothing has been cured in decades even doe we've had dna for many many decades lol Quote Link to comment Share on other sites More sharing options...
CitizenVectron Posted October 22, 2019 Author Share Posted October 22, 2019 2 hours ago, TomCat said: even doe we've had dna for many many decades I would argue it's been even longer. 4 Quote Link to comment Share on other sites More sharing options...
GeneticBlueprint Posted October 22, 2019 Share Posted October 22, 2019 26 minutes ago, Massdriver said: My eye doctor doctor started talking about how they have probably had a cure for cancer, but money has kept it from the public. I was disappointed. A lot of really intelligent people still believe these conspiracies unfortunately. If such conspiracies were true, that would mean that a lot of lower paid research scientists have all decided not to blow a whistle on the ethics of holding it all back which is implausible. You should probably not go back to that doctor. Quote Link to comment Share on other sites More sharing options...
GeneticBlueprint Posted October 22, 2019 Share Posted October 22, 2019 1 minute ago, CitizenVectron said: I would argue it's been even longer. I mean, at least a century. Quote Link to comment Share on other sites More sharing options...
Massdriver Posted October 22, 2019 Share Posted October 22, 2019 7 minutes ago, GeneticBlueprint said: You should probably not go back to that doctor. The fact I typed doctor twice seems to be a good indication of how tired I am right now. Quote Link to comment Share on other sites More sharing options...
dualhunter Posted October 22, 2019 Share Posted October 22, 2019 8 minutes ago, Massdriver said: The fact I typed doctor twice seems to be a good indication of how tired I am right now. Either that or a good indication of how much you need a good eye doctor Quote Link to comment Share on other sites More sharing options...
Reputator Posted October 22, 2019 Share Posted October 22, 2019 I know everyone's all excited about ending human disease, but like... Quote Link to comment Share on other sites More sharing options...
Jwheel86 Posted October 22, 2019 Share Posted October 22, 2019 5 hours ago, TomCat said: it wong happen cause there is no money in curing things the money is in the treatment. thats why Nothing has been cured in decades even doe we've had dna for many many decades Google Zolgensma, cures the leading genetic killer of infants. Fully approved. Quote Link to comment Share on other sites More sharing options...
Uaarkson Posted October 22, 2019 Share Posted October 22, 2019 So this shit is going to wind up being available mostly to just the rich, right? I would love to be proven wrong on that one. Quote Link to comment Share on other sites More sharing options...
Kal-El814 Posted October 22, 2019 Share Posted October 22, 2019 9 hours ago, Jwheel86 said: Google Zolgensma, cures the leading genetic killer of infants. Fully approved. Also, the “grail” of treatment for MANY afflictions is vaccinations or other preventative treatments. The market for a potential breast cancer cure is everyone who gets breast cancer. The market for a preventative breast cancer vaccination is everyone with breasts. Quote Link to comment Share on other sites More sharing options...
Jwheel86 Posted October 22, 2019 Share Posted October 22, 2019 9 hours ago, Uaarkson said: So this shit is going to wind up being available mostly to just the rich, right? I would love to be proven wrong on that one. Zolgensma ($2.1 million) is free if your insurance denies you twice. The medication I receive has cost north of $1.5 million so far and has had zero out of pocket costs. Quote Link to comment Share on other sites More sharing options...
b_m_b_m_b_m Posted October 22, 2019 Share Posted October 22, 2019 7 minutes ago, Kal-El814 said: Also, the “grail” of treatment for MANY afflictions is vaccinations or other preventative treatments. The market for a potential breast cancer cure is everyone who gets breast cancer. The market for a preventative breast cancer vaccination is everyone with breasts. Vaccinations? Why would I want autism? Quote Link to comment Share on other sites More sharing options...
Chadatog Posted October 22, 2019 Share Posted October 22, 2019 Speaking of health and science type stuff, anyone catch our own Lopez on the recent episode of America Dissected, it's a podcast and that episode is about opioid and crack addiction. @SFLUFAN Quote Link to comment Share on other sites More sharing options...
Commissar SFLUFAN Posted October 22, 2019 Share Posted October 22, 2019 5 minutes ago, Chadatog said: Speaking of health and science type stuff, anyone catch our own Lopez on the recent episode of America Dissected, it's a podcast and that episode is about opioid and crack addiction. @SFLUFAN Oh - I had no idea! I'll have to check that out! Quote Link to comment Share on other sites More sharing options...
elbobo Posted October 22, 2019 Share Posted October 22, 2019 Bring on full bore human genetic manipulation, I am not being sarcastic Quote Link to comment Share on other sites More sharing options...
Jason Posted October 22, 2019 Share Posted October 22, 2019 Just now, elbobo said: Bring on full bore human genetic manipulation, I am not being sarcastic Quote Link to comment Share on other sites More sharing options...
Jwheel86 Posted October 22, 2019 Share Posted October 22, 2019 Can I plug episode 2 of Unnatural Selection on Netflix? It's about cost of rare disease treatment and has a guy with my disability. Quote Link to comment Share on other sites More sharing options...
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