Commissar SFLUFAN Posted July 22, 2022 Share Posted July 22, 2022 If true...Jesus Christ Almighty Two decades of Alzheimer's research may be based on deliberate fraud that has cost millions of lives DAILYKOS.COM Last month, drug company Genentech reported on the first clinical trials of the drug crenezumab, a drug targeting amyloid proteins that form sticky plaques in the brains of Alzheimer’s disease patients... Quote Last month, drug company Genentech reported on the first clinical trials of the drug crenezumab, a drug targeting amyloid proteins that form sticky plaques in the brains of Alzheimer’s disease patients. The drug had been particularly effective in animal models, and the trial results were eagerly awaited as one of the most promising treatments in years. It did not work. “Crenezumab did not slow or prevent cognitive decline” in people with a predisposition toward Alzheimer’s. Last year, the Food and Drug Administration (FDA) narrowly approved the use of Aduhelm, a new drug from Biogen that the company has priced so highly that it’s expected to drive up the price of Medicare for everyone in America, even those who never need this drug. Aduhelm was the first drug to be approved that fights the accumulation of those "amyloid plaques" in the brain. What makes the approval of the $56,000-a-dose drug so controversial is that while it does decrease plaques, it doesn’t actually slow Alzheimer’s. In fact, clinical trials were suspended in 2019 after the treatment showed “no clinical benefits.” (Which did not keep Biogen from seeking the drug’s approval or pricing it astronomically.) Over the last two decades, Alzheimer’s drugs have been notable mostly for having a 99% failure rate in human trials. It’s not unusual for drugs that are effective in vitro and in animal models to turn out to be less than successful when used in humans, but Alzheimer’s has a record that makes the batting average in other areas look like Hall of Fame material. And now we have a good idea of why. Because it looks like the original paper that established the amyloid plaque model as the foundation of Alzheimer’s research over the last 16 years might not just be wrong, but a deliberate fraud. 2 1 Quote Link to comment Share on other sites More sharing options...
Mr.Vic20 Posted July 22, 2022 Share Posted July 22, 2022 Fuck. Quote Link to comment Share on other sites More sharing options...
CayceG Posted July 22, 2022 Share Posted July 22, 2022 We've wasted 20 years chasing a lie. How many more people are going to die this horrid death because of this detour? People should hang for this. Quote Link to comment Share on other sites More sharing options...
Commissar SFLUFAN Posted July 22, 2022 Author Share Posted July 22, 2022 1 minute ago, CayceG said: We've wasted 20 years chasing a lie. How many more people are going to die this horrid death because of this detour? People should hang for this. If there ever was a situation that "justifies" the use of the death penalty, this definitely qualifies in my mind. 1 Quote Link to comment Share on other sites More sharing options...
Jason Posted July 22, 2022 Share Posted July 22, 2022 Quote Link to comment Share on other sites More sharing options...
Guest Posted July 22, 2022 Share Posted July 22, 2022 Any more medical science oriented sources available on this. Would be rather huge if true. Quote Link to comment Share on other sites More sharing options...
Commissar SFLUFAN Posted July 22, 2022 Author Share Posted July 22, 2022 5 minutes ago, sblfilms said: Any more medical science oriented sources available on this. Would be rather huge if true. At this point, Nature has placed this disclaimer on the paper: Quote 14 July 2022 Editor's Note: The editors of Nature have been alerted to concerns regarding some of the figures in this paper. Nature is investigating these concerns, and a further editorial response will follow as soon as possible. In the meantime, readers are advised to use caution when using results reported therein. This is the investigation by Science: Potential fabrication in research images threatens key theory of Alzheimer’s disease WWW.SCIENCE.ORG A neuroscience sleuth challenges data showing one toxic form of amyloid protein is a cause of brain condition Quote Link to comment Share on other sites More sharing options...
legend Posted July 22, 2022 Share Posted July 22, 2022 If this is true, it's really crazy that this took this long to surface. Academia needs to do a much better job incentivizing replication studies. But those are never sexy and won't get you tenure, so here we are. Quote Link to comment Share on other sites More sharing options...
Commissar SFLUFAN Posted July 22, 2022 Author Share Posted July 22, 2022 8 minutes ago, legend said: If this is true, it's really crazy that this took this long to surface. Academia needs to do a much better job incentivizing replication studies. But those are never sexy and won't get you tenure, so here we are. That's the crux of the discussion in the ResetERA thread on this topic, especially the lack of any incentivization (financial or otherwise) to perform replication studies. 1 Quote Link to comment Share on other sites More sharing options...
legend Posted July 22, 2022 Share Posted July 22, 2022 9 minutes ago, Commissar SFLUFAN said: That's the crux of the discussion in the ResetERA thread on this topic, especially the lack of any incentivization (financial or otherwise) to perform replication studies. Yeah and the thing is, I suspect the scientists themselves would enjoy having it incentivized. CS is a little different than other sciences since its closer to engineering and mathematics, and that has the benefit that it has an degree of implicit replication, but even there I know myself and many others have often talked about making a replication journal because it would be so useful. The interest is there intellectually, but the incentives are not. Of course, it's not just replication. So much of the academic incentive structure is majorly fucked and is one of the reasons I left proper academia. It's barely adequate and far from what science ought to be. /grumble Quote Link to comment Share on other sites More sharing options...
Commissar SFLUFAN Posted July 22, 2022 Author Share Posted July 22, 2022 11 minutes ago, legend said: Of course, it's not just replication. So much of the academic incentive structure is majorly fucked and is one of the reasons I left proper academia. It's barely adequate and far from what science ought to be. The exact phrasing used in the ResetERA thread is that academia is rife with "perverse incentivization". Quote Link to comment Share on other sites More sharing options...
legend Posted July 22, 2022 Share Posted July 22, 2022 3 minutes ago, Commissar SFLUFAN said: The exact phrasing used in the ResetERA thread is that academia is rife with "perverse incentivization". That sounds about right to me! Quote Link to comment Share on other sites More sharing options...
mclumber1 Posted July 23, 2022 Share Posted July 23, 2022 Society would have been better off using alchemy to fight Alzheimers compared to this, potentially! Quote Link to comment Share on other sites More sharing options...
marioandsonic Posted July 23, 2022 Share Posted July 23, 2022 Quote Link to comment Share on other sites More sharing options...
chakoo Posted July 23, 2022 Share Posted July 23, 2022 So judgment might have been on to something. https://en.wikipedia.org/wiki/Judgment_(video_game) Quote Link to comment Share on other sites More sharing options...
unogueen Posted July 23, 2022 Share Posted July 23, 2022 capitalism, always capitalism. When will people wake up to what it really means Quote Link to comment Share on other sites More sharing options...
unogueen Posted July 23, 2022 Share Posted July 23, 2022 20 hours ago, mclumber1 said: Society would have been better off using alchemy to fight Alzheimers compared to this, potentially! alchemy is a loaded term. It describes a specific insinuation, but casts bias on history. The western history would have you believe that modernity was a miracle big bang, not a series of events. But whatever, ruling class and all. Quote Link to comment Share on other sites More sharing options...
BloodyHell Posted July 23, 2022 Share Posted July 23, 2022 13 minutes ago, unogueen said: alchemy is a loaded term. It describes a specific insinuation, but casts bias on history. The western history would have you believe that modernity was a miracle big bang, not a series of events. But whatever, ruling class and all. If you said much less, you'd make more sense. 1 1 Quote Link to comment Share on other sites More sharing options...
mclumber1 Posted July 23, 2022 Share Posted July 23, 2022 Alchemy is @unogueen's trigger word. Sorry that I upset you, bud. 1 Quote Link to comment Share on other sites More sharing options...
Ricofoley Posted July 23, 2022 Share Posted July 23, 2022 Wait, so am I understanding this right that it's not just this particular treatment for the plaque that's called into question by this, but the entire idea that this plaque being built up is what causes alzheimers? Is that correct? 'Cause... man, I thought that was like a well-established fact at this point. That's gutting. Quote Link to comment Share on other sites More sharing options...
unogueen Posted July 23, 2022 Share Posted July 23, 2022 5 minutes ago, BloodyHell said: If you said much less, you'd make more sense. buddy im bored.and college took the love of writing from me. Quote Link to comment Share on other sites More sharing options...
CitizenVectron Posted July 23, 2022 Share Posted July 23, 2022 7 minutes ago, unogueen said: buddy im bored.and college took the love of writing from me. It appears to have also taken the skill. 1 1 Quote Link to comment Share on other sites More sharing options...
unogueen Posted July 23, 2022 Share Posted July 23, 2022 I'm not doing pro work for free Quote Link to comment Share on other sites More sharing options...
unogueen Posted July 23, 2022 Share Posted July 23, 2022 15 minutes ago, Ricofoley said: Wait, so am I understanding this right that it's not just this particular treatment for the plaque that's called into question by this, but the entire idea that this plaque being built up is what causes alzheimers? Is that correct? 'Cause... man, I thought that was like a well-established fact at this point. That's gutting. Seriously though. That always sounded off for me. My grandmother had Alzheimers and learned about it in college. Compared to the regiment of most things, that felt really porous. Quote Link to comment Share on other sites More sharing options...
Guest Posted July 23, 2022 Share Posted July 23, 2022 18 minutes ago, Ricofoley said: Wait, so am I understanding this right that it's not just this particular treatment for the plaque that's called into question by this, but the entire idea that this plaque being built up is what causes alzheimers? Is that correct? 'Cause... man, I thought that was like a well-established fact at this point. That's gutting. Correct, there is legitimate reason to believe the plaque theory was fraud and has no basis in reality. Quote Link to comment Share on other sites More sharing options...
Uaarkson Posted July 23, 2022 Share Posted July 23, 2022 1 hour ago, unogueen said: alchemy is a loaded term. It describes a specific insinuation, but casts bias on history. The western history would have you believe that modernity was a miracle big bang, not a series of events. But whatever, ruling class and all. Someone get this man a Mark Twain award. 1 Quote Link to comment Share on other sites More sharing options...
unogueen Posted July 23, 2022 Share Posted July 23, 2022 Are you the same person in real life as the internet? Quote Link to comment Share on other sites More sharing options...
legend Posted July 23, 2022 Share Posted July 23, 2022 1 hour ago, unogueen said: capitalism, always capitalism. When will people wake up to what it really means That problems with academia have little to do with capitalism. Quote Link to comment Share on other sites More sharing options...
CitizenVectron Posted July 23, 2022 Share Posted July 23, 2022 24 minutes ago, unogueen said: Are you the same person in real life as the internet? Well they're a real person, so they've got you beat there. Quote Link to comment Share on other sites More sharing options...
unogueen Posted July 23, 2022 Share Posted July 23, 2022 14 minutes ago, legend said: That problems with academia have little to do with capitalism. Do you not think predatory behaviours don't exist in academia? hew, im a baby, science is pure Quote Link to comment Share on other sites More sharing options...
Air_Delivery Posted July 23, 2022 Share Posted July 23, 2022 1 hour ago, Ricofoley said: Wait, so am I understanding this right that it's not just this particular treatment for the plaque that's called into question by this, but the entire idea that this plaque being built up is what causes alzheimers? Is that correct? 'Cause... man, I thought that was like a well-established fact at this point. That's gutting. Nah its been in question for awhile. It seems that the plaque might be the result of alzhemiers not the cause. Kinda like thinking cleaning up debris is going to stop a tornado. Quote Link to comment Share on other sites More sharing options...
legend Posted July 23, 2022 Share Posted July 23, 2022 1 hour ago, unogueen said: Do you not think predatory behaviours don't exist in academia? hew, im a baby, science is pure My man, I have a PhD and did a postdoc after that before leaving for industry and you can see in the previous posts I made in this very thread that I have numerous problems with academia as it is. Its problems still don't have much to do with capitalism. Quote Link to comment Share on other sites More sharing options...
unogueen Posted July 23, 2022 Share Posted July 23, 2022 How about predatory publishers? Quote Link to comment Share on other sites More sharing options...
CitizenVectron Posted July 23, 2022 Share Posted July 23, 2022 14 minutes ago, legend said: My man, I have a PhD and did a postdoc after that before leaving for industry and you can see in the previous posts I made in this very thread that I have numerous problems with academia as it is. Its problems still don't have much to do with capitalism. Unogueen thinks that anything wrong related to money is related to capitalism, because he doesn't understand that money isn't capitalism. 1 Quote Link to comment Share on other sites More sharing options...
legend Posted July 24, 2022 Share Posted July 24, 2022 14 minutes ago, unogueen said: How about predatory publishers? What about them? There are lots of issues with publishers and complicated aspects of it, but the core rot of even that is the way universities set up their promotion metrics around them and the grant incentives for the kind of work you publish. Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You can post now and register later. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.